A multipartite virus, multipart virus, or hybrid virus is one that infects both the master boot record and executable files on a hard drive in staggered stages. As they can infect more than one part of the system at once, they are the most devastating of all computer virus types. These hybrid viruses are often hard to remove and, unless completely eradicated, can reinfect the host system again.

Discovered by Friðrik Skúlason in 1989, the Ghostball virus was the first multipartite virus.

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